Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13674562 | 0.92 | KDM4E (0.36) | KDM4EALDH1A1KCNH2HDAC1TTR | |
| SCHEMBL4522841 | 0.82 | PTPN11 (0.39) | ALDH1A1KCNH2HDAC1CCR2HSD11B1 | |
| SCHEMBL4522833 | 0.82 | PTPN11 (0.39) | ALDH1A1KCNH2HDAC1CCR2HSD11B1 | |
| SCHEMBL13674434 | 0.81 | HSD11B1 (0.42) | ALDH1A1TTRFDPSHTTHSD11B1 | |
| SCHEMBL13675623 | 0.79 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL4519356 | 0.78 | HSD11B1 (0.49) | ALDH1A1HDAC1NR1H4GPR183HSD11B1 | |
| SCHEMBL4519361 | 0.78 | HSD11B1 (0.49) | ALDH1A1HDAC1NR1H4GPR183HSD11B1 | |
| SCHEMBL4508780 | 0.76 | HSD11B1 (0.37) | ALDH1A1CCR2GPR183HSD11B1 | |
| SCHEMBL13675467 | 0.75 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL13674485 | 0.73 | OPRM1 (0.39) | ALDH1A1MAPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264650-A1 | Prophylactic/Therapeutic Agent for Diabetes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264650-A1 | Prophylactic/Therapeutic Agent for Diabetes | HSD11B1, HSD17B1, HSD11B2 | KDM4E 2703/4885ALDH1A1 51/4885KCNH2 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.