Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 20/20 | 0.44 |
| ▸ | MC5R | P33032 | 19/20 | 0.44 |
| ▸ | MC3R | P41968 | 11/20 | 0.44 |
| ▸ | MC1R | Q01726 | 9/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13677284 | 0.87 | MC4R (0.44) | MC4RMC5RMC3RMC1R | |
| SCHEMBL13677292 | 0.84 | MC4R (0.46) | MC4RMC5RMC3RMC1R | |
| SCHEMBL14111012 | 0.83 | MC4R (0.45) | MC4RMC5RMC3RMC1R | |
| SCHEMBL12153171 | 0.79 | HRH3 (0.44) | — | |
| SCHEMBL14585935 | 0.78 | MC4R (0.49) | MC4RMC5RMC3RMC1R | |
| SCHEMBL14519040 | 0.78 | HRH3 (0.43) | — | |
| SCHEMBL1324396 | 0.77 | EPHX1 (0.50) | MC4RMC5RMC3RMC1R | |
| SCHEMBL1325197 | 0.77 | MC4R (0.42) | MC4RMC5RMC3RMC1R | |
| SCHEMBL1324395 | 0.73 | MC4R (0.40) | MC4RMC5RMC3RMC1R | |
| SCHEMBL12153228 | 0.72 | LMNA (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8334290-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-18 | — | — | US | disclosed |
| US-20090264405-A1 | Cetp Inhibitors | MERCK SHARP & DOHME LLC | 2009-10-22 | — | — | US | disclosed |
| WO-2007070173-A2 | CETP INHIBITORS | MERCK & CO., INC. (US) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264405-A1 | Cetp Inhibitors | CETP, APOB, PCSK9 | MC4R 2976/4885MC5R 3921/4885MC3R 3858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.