Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679579 | 0.90 | PDE2A (0.53) | MAPTMEN1KMT2APDE2APRMT5 | |
| SCHEMBL1268279 | 0.85 | MAPT (0.85) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679539 | 0.85 | MAPT (0.67) | MAPTMEN1HTTKMT2ACASP3 | |
| SCHEMBL13679575 | 0.82 | MAPT (0.73) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679580 | 0.81 | MAPT (0.67) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL13679552 | 0.81 | MAPT (0.69) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL16029174 | 0.80 | MAPT (0.70) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14615282 | 0.80 | MAPT (0.68) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL14642415 | 0.80 | MAPT (0.65) | MAPTMEN1HTTKMT2AKDM4E | |
| SCHEMBL15424127 | 0.79 | MAPT (0.68) | MAPTMEN1HTTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772275-B2 | Mediators of hedgehog signaling pathways, compositions and uses related thereto | CURIS, INC. (US) | 2014-07-08 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |