Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.79 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | RECQL | P46063 | 2/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679550 | 0.85 | MAPT (0.70) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL14615293 | 0.85 | MAPT (0.72) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL13679553 | 0.84 | MAPT (0.71) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL3690267 | 0.83 | MMP2 (0.63) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL14615292 | 0.82 | MAPT (0.69) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL16782299 | 0.80 | MAPT (1.00) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL14615280 | 0.80 | IRAK4 (0.66) | MAPTALDH1A1KMT2AMEN1IRAK4 | |
| SCHEMBL14615274 | 0.79 | MAPT (0.80) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL25956571 | 0.78 | IRAK4 (0.81) | MAPTALDH1A1KMT2AMEN1IRAK4 | |
| SCHEMBL14615278 | 0.77 | MAPT (1.00) | MAPTALDH1A1KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-1482928-B1 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS,COMPOSITIONS AND USES RELATED THERETO | CURIS INC (US) | 2009-09-23 | — | — | EP | disclosed |