Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | SMO | Q99835 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 3/20 | 0.60 |
| ▸ | NRP1 | O14786 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615293 | 0.88 | MAPT (0.72) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL13679553 | 0.87 | MAPT (0.71) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL13679550 | 0.86 | MAPT (0.70) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL14615278 | 0.82 | MAPT (1.00) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL13679543 | 0.82 | MAPT (0.79) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL25211422 | 0.81 | MAPK14 (0.79) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL30445799 | 0.81 | MAPK14 (0.79) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL16782299 | 0.81 | MAPT (1.00) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL14615274 | 0.80 | MAPT (0.80) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL14615276 | 0.80 | MAPT (0.76) | MAPTCYP1A2CYP3A4CYP2C19NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |