Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679706 | 0.89 | ACHE (0.43) | ABCB1MAPTSMN1; SMN2KDM4EGAA | |
| SCHEMBL13679697 | 0.81 | ABCB1 (0.62) | ABCB1MAPTLMNASIRT2SIRT1 | |
| SCHEMBL3827087 | 0.80 | ABCB1 (0.44) | ABCB1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL3827085 | 0.80 | ABCB1 (0.44) | ABCB1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL13679681 | 0.78 | ABCB1 (0.43) | ABCB1MAPTLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL13679752 | 0.76 | ABCB1 (0.48) | ABCB1 | |
| SCHEMBL13679705 | 0.76 | ABCB1 (0.67) | ABCB1 | |
| SCHEMBL13679704 | 0.76 | ABCB1 (0.42) | ABCB1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL13679672 | 0.76 | ABCB1 (0.56) | ABCB1MAPTSIRT2SIRT1SMN1; SMN2 | |
| SCHEMBL13679678 | 0.76 | ABCB1 (0.63) | ABCB1MAPTLMNASIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-B1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | TAIJI BIOMEDICAL INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2082740-A2 | Use of imidazole derivatives as MDR modulators | Taiji Biomedical, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |