Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679681 | 0.91 | ABCB1 (0.43) | ABCB1KDM4EMEN1NPC1MAPT | |
| SCHEMBL3827085 | 0.82 | ABCB1 (0.44) | ABCB1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL3827087 | 0.82 | ABCB1 (0.44) | ABCB1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL13679752 | 0.81 | ABCB1 (0.48) | ABCB1APP | |
| SCHEMBL13679705 | 0.79 | ABCB1 (0.67) | ABCB1 | |
| SCHEMBL13679748 | 0.77 | ABCB1 (0.52) | ABCB1APP | |
| SCHEMBL13679694 | 0.76 | ABCB1 (0.40) | ABCB1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL13679706 | 0.76 | ACHE (0.43) | ABCB1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL4442601 | 0.71 | ABCB1 (0.68) | ABCB1MEN1MAPTKMT2A | |
| SCHEMBL13679647 | 0.70 | ABCB1 (0.53) | ABCB1KDM4EMEN1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-B1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | TAIJI BIOMEDICAL INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2082740-A2 | Use of imidazole derivatives as MDR modulators | Taiji Biomedical, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |