Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.62 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | PTAFR | P25105 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056834 | 0.86 | CRBN (0.61) | MAPTPOLBCTDSP1MKNK1MKNK2 | |
| SCHEMBL14210412 | 0.83 | CRBN (0.58) | MAPTPOLBCTDSP1CRBNMMP13 | |
| SCHEMBL18317076 | 0.83 | HPGDS (0.59) | MAPTPOLBCTDSP1MKNK1MKNK2 | |
| SCHEMBL2026287 | 0.81 | NPC1 (0.67) | MAPTPOLBCTDSP1MKNK1MKNK2 | |
| SCHEMBL16574182 | 0.81 | MMP13 (0.69) | MAPTPOLBMKNK1MKNK2HDAC2 | |
| SCHEMBL16198923 | 0.81 | HDAC6 (0.70) | CTDSP1MKNK1MKNK2HDAC2CRBN | |
| SCHEMBL14115137 | 0.81 | HDAC6 (0.70) | CTDSP1MKNK1MKNK2HDAC2CRBN | |
| SCHEMBL4428711 | 0.80 | MAPT (0.64) | MAPTPOLBCTDSP1HSD17B1HSD17B2 | |
| SCHEMBL31331712 | 0.80 | RXRA (0.69) | MAPTPOLBCTDSP1HSD17B1HSD17B2 | |
| SCHEMBL2610268 | 0.80 | RXRA (0.69) | MAPTPOLBCTDSP1HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |