Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.56 |
| ▸ | CCR8 | P51685 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11287805 | 0.88 | MEN1 (0.52) | RAB9AAPPMAPTSMN1; SMN2ADK | |
| SCHEMBL3422361 | 0.85 | CCR1 (0.75) | CCR1CCR8RAB9ACYP2A6MAPT | |
| SCHEMBL2614970 | 0.79 | CCR1 (0.65) | CCR1CCR8NPC1RAB9AL3MBTL1 | |
| SCHEMBL18730183 | 0.79 | ASIC3 (0.60) | APPMAPTSMN1; SMN2ADKALDH1A1 | |
| SCHEMBL2189142 | 0.78 | KMT2A (0.62) | CCR1CCR8NPC1RAB9AL3MBTL1 | |
| SCHEMBL647992 | 0.77 | MEN1 (0.68) | CCR1CCR8NPC1RAB9ACYP2A6 | |
| SCHEMBL29963679 | 0.77 | MEN1 (0.68) | CCR1CCR8NPC1RAB9ACYP2A6 | |
| SCHEMBL9848050 | 0.76 | MAPT (0.47) | NPC1RAB9AAPPMAPTSMN1; SMN2 | |
| SCHEMBL16189110 | 0.76 | CCR1 (0.60) | CCR1CCR8RAB9ACYP2A6MAPT | |
| SCHEMBL2615266 | 0.76 | CCR1 (0.60) | CCR1CCR8NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |