Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | CCNC | P24863 | 4/20 | 0.40 |
| ▸ | CDK8 | P49336 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680907 | 0.76 | APP (0.42) | APPTRPA1FAAHARCCNC | |
| SCHEMBL23638931 | 0.72 | TRPA1 (0.60) | APPTRPA1FAAHARCCNC | |
| SCHEMBL13680579 | 0.72 | NR3C1 (0.60) | APPTRPA1FAAHARCCNC | |
| SCHEMBL21412250 | 0.71 | USP7 (0.56) | APPTRPA1FAAHARCCNC | |
| SCHEMBL16364359 | 0.71 | TRPA1 (0.51) | APPTRPA1FAAHARCCNC | |
| SCHEMBL424964 | 0.71 | TRPA1 (0.46) | APPTRPA1MAPT | |
| SCHEMBL29769166 | 0.71 | TRPA1 (0.46) | APPTRPA1MAPT | |
| SCHEMBL15344917 | 0.71 | TRPA1 (0.48) | APPTRPA1FAAHARCCNC | |
| SCHEMBL15345075 | 0.71 | TRPA1 (0.48) | APPTRPA1FAAHARCCNC | |
| SCHEMBL15344153 | 0.71 | TRPA1 (0.48) | APPTRPA1FAAHARCCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |