Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.62 |
| ▸ | NQO2 | P16083 | 8/20 | 0.53 |
| ▸ | TOP2A | P11388 | 3/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680452 | 0.83 | GSK3B (0.61) | GSK3BNQO2ALDH1A1HPGDKDM4E | |
| SCHEMBL13680465 | 0.83 | GSK3B (0.61) | GSK3BNQO2ALDH1A1HPGDTDP1 | |
| SCHEMBL13680701 | 0.81 | TOP2A (0.53) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL13681277 | 0.81 | MAPT (0.51) | GSK3BNQO2ALDH1A1HPGDTDP1 | |
| SCHEMBL23197679 | 0.79 | TDP1 (0.56) | GSK3BNQO2TOP2ATOP2BALDH1A1 | |
| SCHEMBL13680494 | 0.79 | ALDH1A1 (0.46) | GSK3BNQO2ALDH1A1HPGDKDM4E | |
| SCHEMBL5655892 | 0.79 | GSK3B (0.64) | GSK3BALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL13680504 | 0.79 | PLK1 (0.50) | GSK3BNQO2ALDH1A1HPGDKDM4E | |
| SCHEMBL23863067 | 0.78 | NQO2 (0.53) | NQO2TOP2ATOP2BALDH1A1HPGD | |
| SCHEMBL31331819 | 0.77 | MAPT (0.50) | GSK3BNQO2ALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |