Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680566 | 0.78 | PRF1 (0.52) | — | |
| SCHEMBL2448407 | 0.78 | KDM4E (0.49) | CYP1A2CYP11B1CYP11B2HSD17B1GRM1 | |
| SCHEMBL13680577 | 0.77 | CLK4 (0.53) | CYP2A6PARP10PARP11TGFBR1GRM5 | |
| SCHEMBL2432038 | 0.77 | CYP1A2 (0.50) | CYP1A2CYP11B1CYP11B2HSD17B1GRM1 | |
| SCHEMBL19734014 | 0.76 | CYP1A2 (0.56) | CYP1A2CYP11B1CYP11B2HSD17B1GRM1 | |
| SCHEMBL3630871 | 0.75 | HSD17B1 (0.54) | CYP1A2CYP11B1CYP11B2HSD17B1GRM1 | |
| SCHEMBL13680642 | 0.75 | PARP10 (0.64) | CYP1A2CYP11B1CYP11B2HSD17B1GRM1 | |
| SCHEMBL28655414 | 0.75 | HSD17B1 (0.78) | CYP1A2CYP11B1CYP11B2HSD17B1GRM1 | |
| SCHEMBL20865266 | 0.73 | CCR1 (0.54) | CCR1CCR8CYP2A6TGFBR1 | |
| SCHEMBL1747435 | 0.73 | HSD17B1 (0.69) | CYP1A2CYP11B1CYP11B2HSD17B1GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |