Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | PRF1 | P14222 | 5/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31267870 | 0.78 | CLK4 (0.52) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL13680735 | 0.78 | HSD17B1 (0.48) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL13681013 | 0.78 | PRF1 (0.43) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL15984853 | 0.76 | GSK3B (0.56) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL13680620 | 0.76 | PRF1 (0.55) | PRF1GLA | |
| SCHEMBL3873312 | 0.76 | CYP2E1 (0.43) | TGFBR1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL13680577 | 0.74 | CLK4 (0.53) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL20923873 | 0.73 | PRF1 (0.62) | GSK3BCLK4DAPK3NTRK1PIM1 | |
| SCHEMBL13680630 | 0.73 | PDE3B (0.57) | TGFBR1ACVR1 | |
| SCHEMBL13680628 | 0.71 | CRBN (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |