Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 6/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17212950 | 0.73 | ALDH1A1 (0.53) | TDP1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL13680725 | 0.72 | ADORA2A (0.51) | TDP1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL12578009 | 0.69 | TDP1 (0.67) | TDP1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL14220727 | 0.69 | KDM4E (0.46) | TDP1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL13680974 | 0.69 | ALDH1A1 (0.35) | TDP1ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL13680719 | 0.67 | DYRK1A (0.53) | HPGDHSD17B10MEN1KMT2A | |
| SCHEMBL10064162 | 0.67 | TDP1 (0.62) | TDP1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL11983826 | 0.67 | TDP1 (0.62) | TDP1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL21929982 | 0.67 | TDP1 (0.62) | TDP1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL2319851 | 0.67 | TDP1 (0.48) | TDP1ALDH1A1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |