Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28463384 | 0.77 | ADORA2A (0.55) | ADORA2AADORA1ADORA3BRD4DYRK1A | |
| SCHEMBL13680721 | 0.75 | ADORA2A (0.43) | ADORA2AADORA1ADORA3ADORA2BCREBBP | |
| SCHEMBL22579156 | 0.74 | ADORA2A (0.48) | ADORA2AADORA1ADORA3BRD4ADORA2B | |
| SCHEMBL23197679 | 0.73 | TDP1 (0.56) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL29907698 | 0.73 | ADORA2A (0.47) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL22552045 | 0.73 | ADORA2A (0.47) | ADORA2AADORA1ADORA3ADORA2BKDM4E | |
| SCHEMBL29907757 | 0.72 | ADORA2A (0.48) | ADORA2AADORA1ADORA3BRD4DYRK1A | |
| SCHEMBL13680601 | 0.72 | TDP1 (0.39) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL16573986 | 0.71 | BRD4 (0.50) | BRD4DYRK1ACREBBP | |
| SCHEMBL2319851 | 0.68 | TDP1 (0.48) | KDM4ENPC1ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |