Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.46 |
| ▸ | MERTK | Q12866 | 5/20 | 0.44 |
| ▸ | AXL | P30530 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680570 | 0.78 | PIK3C3 (0.39) | DYRK1ATGFBR1MERTKAXLFLT3 | |
| SCHEMBL14826052 | 0.75 | DYRK1A (0.85) | DYRK1ATGFBR1MERTKAXLFLT3 | |
| SCHEMBL13681028 | 0.73 | DYRK1A (0.43) | DYRK1ATGFBR1MERTKAXLFLT3 | |
| SCHEMBL17643865 | 0.72 | DYRK1A (0.57) | DYRK1ATGFBR1KEAP1CYP3A4MEN1 | |
| SCHEMBL15743398 | 0.71 | DYRK1A (0.60) | DYRK1ATGFBR1TGFBR2PDE4APDE3A | |
| SCHEMBL31380869 | 0.71 | DYRK1A (0.54) | DYRK1ATGFBR1NFKB1MEN1KMT2A | |
| SCHEMBL87222 | 0.70 | DYRK1A (0.53) | DYRK1ATGFBR1TGFBR2PDE4APDE3A | |
| SCHEMBL17930295 | 0.70 | TGFBR1 (0.64) | DYRK1ATGFBR1MERTKAXLFLT3 | |
| SCHEMBL1576521 | 0.69 | DYRK1A (0.73) | DYRK1ATGFBR1MERTKAXLFLT3 | |
| SCHEMBL18584820 | 0.69 | DYRK1A (1.00) | DYRK1ATGFBR1MERTKAXLFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |