Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758887 | 0.84 | P2RX3 (0.47) | MAPTKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL459230 | 0.83 | MAPT (0.54) | MAPTKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL28968146 | 0.82 | CDK8 (0.51) | MAPTKDM4ELMNAHDAC4SMN1; SMN2 | |
| SCHEMBL13680634 | 0.82 | HDAC4 (0.49) | MAPTALDH1A1KMT2AHDAC4CSNK2A2 | |
| SCHEMBL13680638 | 0.81 | HDAC4 (0.48) | MAPTALDH1A1HDAC4SMN1; SMN2NPC1 | |
| SCHEMBL26759931 | 0.81 | MAPT (0.51) | MAPTKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL17824191 | 0.80 | CA12 (0.51) | MAPTKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL7394802 | 0.80 | CA1 (0.56) | MAPTKDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL28758904 | 0.80 | P2RX3 (0.44) | KDM4EALDH1A1HDAC4MAPK1CSNK2A2 | |
| SCHEMBL29618705 | 0.80 | P2RX3 (0.44) | KDM4EALDH1A1HDAC4MAPK1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |