Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 13/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 13/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758904 | 1.00 | P2RX3 (0.44) | P2RX3P2RX2KDM4EKDM6BKDM5C | |
| SCHEMBL28758887 | 0.94 | P2RX3 (0.47) | P2RX3P2RX2KDM4EALDH1A1ATAD2 | |
| SCHEMBL28758894 | 0.90 | HDAC4 (0.43) | P2RX3P2RX2HDAC4 | |
| SCHEMBL17824191 | 0.86 | CA12 (0.51) | P2RX3P2RX2KDM4EALDH1A1ATAD2 | |
| SCHEMBL17823842 | 0.85 | P2RX3 (0.43) | P2RX3P2RX2ATAD2HDAC4 | |
| SCHEMBL30092203 | 0.81 | HCAR1 (0.46) | P2RX3P2RX2HDAC4 | |
| SCHEMBL17824127 | 0.81 | HCAR1 (0.46) | P2RX3P2RX2HDAC4 | |
| SCHEMBL24071361 | 0.81 | P2RX3 (0.41) | P2RX3P2RX2ATAD2 | |
| SCHEMBL28968146 | 0.81 | CDK8 (0.51) | KDM4EHDAC4 | |
| SCHEMBL13680636 | 0.80 | MAPT (0.58) | KDM4EALDH1A1CSNK2A2CSNK2A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591317-A | P2X3 inhibitors and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-06-07 | — | — | CN | disclosed |