Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 10/20 | 0.63 |
| ▸ | HSD17B2 | P37059 | 10/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | ESRRG | P62508 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842337 | 0.87 | HPGDS (0.69) | HSD17B1HSD17B2MAPTRXFP1TP53 | |
| SCHEMBL3097763 | 0.84 | RAB9A (0.67) | CYP3A4CYP2A6CYP2C9CYP2C19MAPT | |
| SCHEMBL13525288 | 0.83 | HSD17B1 (0.59) | HSD17B1HSD17B2MAPTRXFP1TP53 | |
| SCHEMBL12496709 | 0.83 | KDM4E (0.74) | HSD17B1HSD17B2MAPTRXFP1TP53 | |
| SCHEMBL9910293 | 0.82 | HSD17B1 (0.61) | HSD17B1HSD17B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL15177332 | 0.81 | RAB9A (0.73) | CYP3A4CYP2A6CYP2C9CYP2C19MAPT | |
| SCHEMBL2560736 | 0.81 | HDAC6 (0.69) | HSD17B1HSD17B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL13483897 | 0.81 | CYP3A4 (0.55) | HSD17B1HSD17B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL5714339 | 0.81 | CYP3A4 (0.55) | HSD17B1HSD17B2CYP3A4CYP2A6CYP2C9 | |
| SCHEMBL12994882 | 0.80 | HSD17B1 (0.56) | HSD17B1HSD17B2MAPTRXFP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| EP-1780212-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE | Teijin Pharma Limited (JP) | 2007-05-02 | — | — | EP | disclosed |