Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10898482 | 0.80 | IDO1 (0.50) | IDO1KMONOTUMPARP10PARP11 | |
| SCHEMBL12863970 | 0.79 | LYN (0.44) | LYNMETAP2NPC1ALDH1A1RAB9A | |
| SCHEMBL2352218 | 0.78 | AKT1 (0.52) | LYNCDK2CDK9NPC1ALDH1A1 | |
| SCHEMBL4402515 | 0.77 | HSD17B1 (0.61) | IDO1METAP2XDHKMOBCHE | |
| SCHEMBL21904995 | 0.76 | BTK (0.47) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13680683 | 0.75 | CYP2A6 (0.50) | LYNMETAP2 | |
| SCHEMBL4582273 | 0.75 | AKT1 (0.59) | IDO1METAP2RAB9A | |
| SCHEMBL3422110 | 0.74 | IDO1 (0.58) | IDO1METAP2XDHKMOBCHE | |
| Hydrochloric Acid SCHEMBL23649477 | 0.74 | AKT1 (0.57) | IDO1METAP2RAB9A | |
| SCHEMBL11158919 | 0.74 | SOS1 (0.48) | IDO1METAP2XDHACHENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |