Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680505 | 0.76 | APP (0.49) | APPMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL13680723 | 0.74 | NPC1 (0.49) | ADORA2AADORA1TDP1KAT8MAPT | |
| SCHEMBL13681023 | 0.72 | — | — | |
| SCHEMBL13849841 | 0.69 | ALDH1A1 (0.40) | TDP1KAT8MAPTALOX15KDM4E | |
| SCHEMBL13680709 | 0.68 | GRM5 (0.37) | ADORA2AADORA1TDP1APPMAPT | |
| SCHEMBL10064162 | 0.67 | TDP1 (0.62) | ADORA2AADORA1TDP1MAPTKMT2A | |
| SCHEMBL21929982 | 0.67 | TDP1 (0.62) | ADORA2AADORA1TDP1MAPTKMT2A | |
| SCHEMBL11983826 | 0.67 | TDP1 (0.62) | ADORA2AADORA1TDP1MAPTKMT2A | |
| SCHEMBL12924643 | 0.66 | MAPT (0.44) | ADORA2ATDP1APPMAPTKMT2A | |
| SCHEMBL13680687 | 0.66 | CCR1 (0.55) | ADORA2AADORA1CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |