Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680709 | 0.79 | GRM5 (0.37) | APPRAB9ANPC1GAAKDM4E | |
| SCHEMBL13680469 | 0.78 | NPC1 (0.42) | TDO2RAB9ANPC1GAAKDM4E | |
| SCHEMBL13680714 | 0.76 | ADORA2A (0.36) | APPRAB9ANPC1GAAKDM4E | |
| SCHEMBL13680455 | 0.75 | CYP2A6 (0.45) | RAB9ANPC1GAAKDM4EALDH1A1 | |
| SCHEMBL13680715 | 0.74 | TDP1 (0.42) | RAB9ANPC1GAAKDM4EALDH1A1 | |
| SCHEMBL13680457 | 0.72 | MAPT (0.49) | TDO2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL13680902 | 0.72 | APP (0.40) | APPTDO2MAP3K11RAB9ANPC1 | |
| SCHEMBL23197679 | 0.72 | TDP1 (0.56) | RAB9ANPC1GAAKDM4EALDH1A1 | |
| SCHEMBL19187780 | 0.72 | MAP3K11 (0.47) | APPTDO2MAP3K11RAB9ANPC1 | |
| SCHEMBL13681286 | 0.71 | ALDH1A1 (0.41) | RAB9ANPC1GAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |