Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680719 | 0.78 | DYRK1A (0.53) | DYRK1AHPGDHSD17B10AXLFLT3 | |
| SCHEMBL3323702 | 0.74 | PIK3C3 (0.39) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL10175031 | 0.74 | FGFR3 (0.42) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL14826051 | 0.74 | PIK3C3 (0.51) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL13680906 | 0.74 | PIK3C3 (0.37) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL3185826 | 0.72 | PIK3C3 (0.45) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL31380866 | 0.72 | ADRA2A (0.48) | CYP11B1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL13680536 | 0.71 | TGFBR1 (0.53) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL557143 | 0.70 | SMN1; SMN2 (0.44) | PIK3C3PIK3CDABL1EGFRHCK | |
| SCHEMBL3321672 | 0.70 | CYP1A2 (0.41) | PIK3C3PIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |