SCHEMBL13680746

SCHEMBL13680746

CNc1ncc(-c2nc(C)cs2)cn1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.47
CYP2E1 P05181 1/20 0.47
CYP2A6 P11509 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2B6 P20813 1/20 0.47
APP P05067 1/20 0.42
PDE10A Q9Y233 1/20 0.41
SRC P12931 1/20 0.38
CDK2 P24941 1/20 0.38
ZAP70 P43403 1/20 0.38
SYK P43405 1/20 0.38
MAP4K4 O95819 1/20 0.37
AOC3 Q16853 2/20 0.35
NOS1 P29475 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
RIPK2 O43353 1/20 0.35
RIPK3 Q9Y572 1/20 0.35
IRAK4 Q9NWZ3 3/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13680744 0.81 CYP3A4 (0.53) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL13680747 0.79 CYP2C9 (0.42) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL13681291 0.79 CYP2E1 (0.39) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL13680738 0.78 CYP3A4 (0.50) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL13680748 0.77 CYP2E1 (0.40) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL13680739 0.76 ADORA2A (0.49) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL13680740 0.75 CYP3A4 (0.47) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL15858765 0.75 CYP3A4 (0.47) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL13680615 0.75 CYP2E1 (0.47) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6
SCHEMBL6840352 0.74 CYP3A4 (0.64) CYP3A4CYP2E1CYP2A6CYP2C9CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7582658-B2 Bicyclic compound ASAHI KASEI PHARMA CORPORATION (JP) 2009-09-01 US disclosed
US-7582658-B2 Bicyclic compound ASAHI KASEI PHARMA CORPORATION (JP) 2009-09-01 US disclosed