Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27149440 | 0.77 | CA2 (0.41) | MAOBCYP3A4CYP2D6 | |
| SCHEMBL140190 | 0.77 | CA2 (0.41) | MAOBCYP3A4CYP2D6 | |
| SCHEMBL30824592 | 0.77 | CA2 (0.41) | MAOBCYP3A4CYP2D6 | |
| SCHEMBL28600756 | 0.76 | MAPT (0.45) | MAPTSMN1; SMN2ALOX15HPGDALDH1A1 | |
| SCHEMBL13917260 | 0.74 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL17321020 | 0.73 | MAPT (0.40) | MAPTSMN1; SMN2ALOX15HPGDALDH1A1 | |
| SCHEMBL22868110 | 0.73 | SMN1; SMN2 (0.49) | MAPTSMN1; SMN2ALOX15HPGDALDH1A1 | |
| SCHEMBL8269304 | 0.73 | MAPT (0.49) | MAPTSMN1; SMN2ALOX15HPGDALDH1A1 | |
| SCHEMBL5986723 | 0.72 | MAPT (0.51) | MAPTSMN1; SMN2ALOX15HPGDALDH1A1 | |
| SCHEMBL17321019 | 0.71 | ALDH1A1 (0.41) | MAPTSMN1; SMN2ALOX15ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |