Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.57 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.43 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724480 | 0.86 | AGXT (0.61) | AGXTKMOLMNAPIK3CDPIK3CA | |
| SCHEMBL4576250 | 0.86 | AGXT (0.54) | AGXTSIGMAR1HDAC4MEF2DMAPT | |
| SCHEMBL27526752 | 0.85 | PRMT6 (0.55) | AGXTSIGMAR1HDAC4MEF2DMAPT | |
| SCHEMBL13680782 | 0.83 | SLC13A5 (0.49) | LMNAPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4577362 | 0.82 | AGXT (0.57) | AGXTPLOD2PLOD3PLOD1SIGMAR1 | |
| SCHEMBL8189516 | 0.80 | AGXT (0.61) | AGXTKMOLMNAAOC3PLOD2 | |
| SCHEMBL425652 | 0.80 | AGXT (0.66) | AGXTKMOLMNAAOC3PLOD2 | |
| SCHEMBL13725027 | 0.80 | AGXT (0.66) | AGXTKMOLMNAAOC3PLOD2 | |
| Hydrochloric Acid SCHEMBL5673049 | 0.79 | AGXT (0.60) | AGXTKMOLMNAAOC3PLOD2 | |
| SCHEMBL30151165 | 0.78 | KMO (0.58) | AGXTKMOLMNAAOC3PLOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |