Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.58 |
| ▸ | AGXT | P21549 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.48 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.48 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6252601 | 0.87 | AGXT (0.58) | KMOAGXTMAPTFKBP1AMEN1 | |
| SCHEMBL2554494 | 0.87 | ALDH1A1 (0.55) | AGXTMAPTGAAMEN1KMT2A | |
| SCHEMBL6583384 | 0.85 | ITGB3 (0.64) | KMOAGXTMAPTLMNAMEN1 | |
| SCHEMBL15330250 | 0.85 | ALDH1A1 (0.54) | AGXTMAPTGAAMEN1KMT2A | |
| SCHEMBL29951752 | 0.85 | ALDH1A1 (0.54) | AGXTMAPTGAAMEN1KMT2A | |
| SCHEMBL3048067 | 0.84 | AGXT (0.51) | KMOAGXTMAPTFKBP1AMEN1 | |
| SCHEMBL7530628 | 0.83 | LMNA (0.62) | MAPTFKBP1ALMNAGAAITGB3 | |
| Hydrochloric Acid SCHEMBL11294327 | 0.83 | MAPT (0.50) | KMOAGXTMAPTFKBP1AMEN1 | |
| SCHEMBL3928659 | 0.82 | AGXT (0.52) | KMOAGXTMAPTLMNAAOC3 | |
| Hydrochloric Acid SCHEMBL5673049 | 0.81 | AGXT (0.60) | KMOAGXTMAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551846-B | 1,4,5, 6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2024-03-08 | — | — | CN | claimed |
| WO-2023085396-A1 | PHARMACEUTICAL COMPOSITION FOR PROVIDING TREATMENT FOR OR PREVENTING ALPORT SYNDROME | ＵＢＥ株式会社 | 2023-05-19 | — | — | WO | claimed |
| CN-115551846-A | 1,4,5,6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2022-12-30 | — | — | CN | claimed |
| CN-115551846-B | 1,4,5, 6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2024-03-08 | — | — | CN | disclosed |
| WO-2023085396-A1 | PHARMACEUTICAL COMPOSITION FOR PROVIDING TREATMENT FOR OR PREVENTING ALPORT SYNDROME | ＵＢＥ株式会社 | 2023-05-19 | — | — | WO | disclosed |
| CN-115551846-A | 1,4,5,6-tetrahydropyrimidin-2-amine derivatives | ＵＢＥ株式会社 | 2022-12-30 | — | — | CN | disclosed |