Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 3/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2384628 | 0.84 | MKNK1 (0.57) | MKNK1MKNK2CYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL348856 | 0.81 | CHRNA7 (0.57) | CYP2A6CYP1A2CYP2D6 | |
| SCHEMBL13680808 | 0.81 | EPHX2 (0.38) | EPHX2PRMT6BACE1 | |
| SCHEMBL5990304 | 0.80 | PRMT6 (0.66) | EPHX2PRMT6BACE1MKNK1MKNK2 | |
| SCHEMBL418611 | 0.80 | GPR52 (0.50) | BACE1CYP11B1CYP11B2CYP19A1GPR52 | |
| SCHEMBL5216350 | 0.79 | CHRNA7 (0.65) | EPHX2PRMT6BACE1MKNK1MKNK2 | |
| SCHEMBL1130316 | 0.79 | EPHX2 (0.59) | EPHX2PRMT6BACE1MKNK1MKNK2 | |
| SCHEMBL4468765 | 0.79 | EPHX2 (0.64) | EPHX2PRMT6BACE1MKNK1MKNK2 | |
| SCHEMBL1139185 | 0.79 | EPHX2 (0.59) | EPHX2PRMT6BACE1MKNK1MKNK2 | |
| SCHEMBL1138158 | 0.79 | EPHX2 (0.59) | EPHX2PRMT6BACE1MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |