Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287573 | 0.80 | MBOAT4 (0.33) | MBOAT4PGK1PGK2 | |
| SCHEMBL13680820 | 0.77 | CYP3A4 (0.39) | KCNH2MBOAT4NPSR1MAPTMEN1 | |
| SCHEMBL6193822 | 0.77 | SMN1; SMN2 (0.45) | KCNH2MBOAT4NPSR1MEN1KMT2A | |
| SCHEMBL1463893 | 0.77 | PARP1 (0.36) | KCNH2MBOAT4NPSR1PGK1PGK2 | |
| SCHEMBL8648745 | 0.77 | P2RX7 (0.41) | KCNH2MBOAT4PGK1PGK2 | |
| SCHEMBL13680846 | 0.76 | MAPT (0.40) | MAPT | |
| SCHEMBL24617225 | 0.74 | HRH1 (0.47) | KCNH2MBOAT4MAPT | |
| SCHEMBL28770393 | 0.74 | KCNH2 (0.39) | KCNH2MBOAT4NPSR1MAPT | |
| SCHEMBL10265068 | 0.74 | KCNH2 (0.50) | KCNH2MBOAT4NPSR1MAPT | |
| Formaldehyde SCHEMBL28150017 | 0.73 | KCNH2 (0.46) | KCNH2MBOAT4NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3652164-A1 | PHENYLACETAMIDES AS INHIBITORS OF ROCK | Bristol-Myers Squibb Company (US) | 2020-05-20 | — | — | EP | disclosed |
| WO-2019014300-A1 | PHENYLACETAMIDES AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-17 | — | — | WO | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |