Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680847 | 0.83 | PDE10A (0.43) | TRPV3GRM5SCN9ACYP2A6PDE10A | |
| SCHEMBL13680850 | 0.82 | TRPV3 (0.53) | TRPV3SCN9A | |
| SCHEMBL13680848 | 0.81 | ADK (0.40) | MAPTSCN9ASYK | |
| SCHEMBL13680849 | 0.80 | SCN9A (0.43) | MAPTGRM5SCN9ACYP2A6 | |
| SCHEMBL13680845 | 0.79 | SCN9A (0.41) | TRPV3SCN9APDE10A | |
| SCHEMBL31514156 | 0.79 | MAPT (0.43) | MAPTTRPV3DHODHJAK2RET | |
| SCHEMBL3854280 | 0.79 | MEN1 (0.50) | TRPV3PDE10A | |
| SCHEMBL13680834 | 0.78 | PDE10A (0.39) | MAPTTRPV3PDE10A | |
| SCHEMBL13680818 | 0.77 | TRPV3 (0.52) | TRPV3SCN9APDE10A | |
| SCHEMBL13680852 | 0.77 | CYP2A6 (0.51) | CYP2E1CYP2A6CYP2B6PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |