Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680925 | 0.84 | POLB (0.36) | MAPK1DCUN1D1CXCR2SMN1; SMN2TNKS | |
| SCHEMBL24088760 | 0.80 | NPC1 (0.45) | KDM4EALPLMAPK1DCUN1D1CXCR2 | |
| SCHEMBL28066635 | 0.78 | KDM4E (0.35) | TYMPKDM4EALPLMAPK1DCUN1D1 | |
| SCHEMBL23778736 | 0.77 | NOTUM (0.45) | TYMPKDM4EALPLMAPK1DCUN1D1 | |
| SCHEMBL24088775 | 0.77 | GFER (0.46) | TYMPKDM4EALPLMAPK1DCUN1D1 | |
| SCHEMBL23778726 | 0.77 | TYMP (0.46) | TYMPKDM4EMAPK1NOTUMCHEK2 | |
| SCHEMBL23778730 | 0.77 | MEN1 (0.39) | TYMPKDM4EALPLMAPK1DCUN1D1 | |
| SCHEMBL23778698 | 0.75 | TP53 (0.41) | TYMPKDM4ECXCR2SMN1; SMN2MEN1 | |
| SCHEMBL23778650 | 0.74 | MTNR1A (0.48) | NPC1RAB9ASMN1; SMN2NOTUMMEN1 | |
| SCHEMBL2555001 | 0.72 | KDM4E (0.41) | TYMPKDM4EALPLMAPK1DCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |