Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680928 | 0.84 | TYMP (0.36) | POLBKMT2AMAPK1CXCR2TNKS | |
| SCHEMBL30670275 | 0.81 | MTOR (0.38) | POLBKMT2AL3MBTL1PIN1CYP1A2 | |
| SCHEMBL4880314 | 0.79 | FFAR1 (0.47) | POLBL3MBTL1CYP1A2MAPK1CYP2C19 | |
| SCHEMBL27641126 | 0.78 | ALPL (0.41) | POLBKMT2AL3MBTL1PIN1CYP1A2 | |
| SCHEMBL1436268 | 0.78 | LOXL2 (0.40) | POLBKMT2AL3MBTL1PIN1CYP1A2 | |
| SCHEMBL27871635 | 0.78 | KCNH2 (0.50) | L3MBTL1PIN1CYP1A2CYP2C19ADORA3 | |
| SCHEMBL535052 | 0.78 | PDE5A (0.44) | POLBPIN1ADORA3ADORA2AMAPT | |
| SCHEMBL2093913 | 0.78 | MTOR (0.36) | POLBKMT2AL3MBTL1PIN1CYP1A2 | |
| SCHEMBL4878258 | 0.76 | ADORA3 (0.38) | POLBKMT2AL3MBTL1PIN1CYP1A2 | |
| SCHEMBL4882878 | 0.76 | NR4A2 (0.47) | PIN1CYP1A2MAPK1CASP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |