Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681039 | 0.88 | MAPT (0.43) | KMT2AMAPTTP53LMNAKDM4E | |
| SCHEMBL13680937 | 0.88 | KDM4E (0.52) | KMT2AMAPTTP53LMNAKDM4E | |
| SCHEMBL13680945 | 0.86 | MEN1 (0.52) | KMT2AMAPTTP53LMNAKDM4E | |
| SCHEMBL13680946 | 0.86 | AVPR1B (0.47) | MAPTTP53LMNAKDM4EALDH1A1 | |
| SCHEMBL13680951 | 0.86 | MAPT (0.55) | MAPTTP53LMNAKDM4EALDH1A1 | |
| SCHEMBL13680958 | 0.86 | RXFP1 (0.57) | KMT2AMAPTTP53LMNAKDM4E | |
| SCHEMBL13681055 | 0.85 | KDM4E (0.46) | MAPTTP53LMNAKDM4EALDH1A1 | |
| SCHEMBL13681269 | 0.83 | MAPT (0.47) | KMT2AMAPTTP53LMNAKDM4E | |
| SCHEMBL13680957 | 0.83 | KDM4E (0.50) | MAPTTP53LMNAKDM4EALDH1A1 | |
| SCHEMBL13680933 | 0.83 | SREBF2 (0.51) | KMT2AMAPTTP53LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |