Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680936 | 0.88 | TP53 (0.46) | TP53LMNAPOLBRXFP1MEN1 | |
| SCHEMBL13680934 | 0.88 | TP53 (0.51) | SREBF2TP53LMNAPOLBKDM4E | |
| SCHEMBL13680938 | 0.88 | MEN1 (0.49) | TP53LMNAPOLBKDM4ERXFP1 | |
| SCHEMBL13680940 | 0.87 | TP53 (0.45) | TP53LMNAPOLBRAB9ANPC1 | |
| SCHEMBL13681034 | 0.85 | MEN1 (0.46) | TP53LMNAPOLBRAB9AKDM4E | |
| SCHEMBL13680947 | 0.85 | TP53 (0.46) | SREBF2TP53LMNAPOLBRAB9A | |
| SCHEMBL13680932 | 0.83 | KMT2A (0.47) | TP53LMNAPOLBRAB9AKDM4E | |
| SCHEMBL13681055 | 0.82 | KDM4E (0.46) | TP53LMNAPOLBRAB9ANPC1 | |
| SCHEMBL13681047 | 0.81 | ADRB2 (0.40) | SREBF2ADRB2TP53RAB9AKDM4E | |
| SCHEMBL13680948 | 0.80 | SREBF1 (0.51) | SREBF2TP53LMNARAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |