Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680932 | 0.88 | KMT2A (0.47) | KDM4ERAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL13680945 | 0.88 | MEN1 (0.52) | KDM4ERAB9AMEN1KMT2ALMNA | |
| SCHEMBL13680958 | 0.84 | RXFP1 (0.57) | KDM4ERAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13680946 | 0.84 | AVPR1B (0.47) | KDM4ERAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL13680951 | 0.84 | MAPT (0.55) | KDM4ERAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL13681269 | 0.84 | MAPT (0.47) | KDM4ERAB9ANPC1MEN1KMT2A | |
| SCHEMBL13680943 | 0.84 | RAB9A (0.48) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL13680920 | 0.84 | RAB9A (0.56) | KDM4ERAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL13681044 | 0.84 | MAPT (0.41) | KDM4ERAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13681039 | 0.84 | MAPT (0.43) | KDM4ERAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |