Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680933 | 0.88 | SREBF2 (0.51) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13680936 | 0.86 | TP53 (0.46) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13680938 | 0.85 | MEN1 (0.49) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13680940 | 0.85 | TP53 (0.45) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13681034 | 0.83 | MEN1 (0.46) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13680958 | 0.83 | RXFP1 (0.57) | TP53LMNARXFP1MAPTKDM4E | |
| SCHEMBL13680947 | 0.83 | TP53 (0.46) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13681058 | 0.82 | MAPT (0.37) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13680939 | 0.80 | MAPT (0.47) | TP53LMNARXFP1MAPTPOLB | |
| SCHEMBL13680929 | 0.80 | ALDH1A1 (0.62) | TP53LMNAMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |