Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | DPP4 | P27487 | 6/20 | 0.93 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.93 |
| ▸ | DRD1 | P21728 | 1/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gemifloxacin SCHEMBL2421086 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3141327 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL1237121 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL29408809 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL2421087 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5661711 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5661708 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3281156 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3281159 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5658681 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 967 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118878838-A | Preparation method and application of metal organic framework material for adsorbing quinolone medicines | 新疆畜牧科学院畜牧业质量标准研究所（新疆维吾尔自治区种羊与羊毛羊绒质量安全监督检验中心） | 2024-11-01 | — | — | CN | claimed |
| US-20230414584-A1 | ADMINISTRATION OF ANTIBIOTIC COMPOUNDS FOR THE TREATMENT OF STREPTOCOCCAL INFECTIONS FOR THE TREATMENT OF PSORIASIS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2023-12-28 | — | — | US | claimed |
| CN-116650492-A | Administration of antibiotic compounds for the treatment of streptococcal infections to treat psoriasis | 消化系统疾病中心 | 2023-08-29 | — | — | CN | claimed |
| CN-114814013-B | Method for rapidly screening unknown chemical hazard residues in aquatic products based on high-resolution mass spectrum database | 中国海洋大学 | 2023-06-02 | — | — | CN | claimed |
| EP-4057813-A1 | COMPOSITIONS AND METHODS FOR TREATING HUANGLONGBING DISEASE IN CITRUS | New Life Crop Sciences LLC (US) | 2022-09-21 | — | — | EP | claimed |
| CN-114980736-A | Compositions and methods for treating citrus greening disease | 新生命作物科学有限责任公司 | 2022-08-30 | — | — | CN | claimed |
| CN-114936109-A | Counter-example fault positioning method based on model detection | 南通大学 | 2022-08-23 | — | — | CN | claimed |
| EP-3951263-A1 | METHOD AND SYSTEM FOR MONITORING THE CONTENT OF IRON CONTAINING MATERIALS IN A PARTICULATE ASH STREAM OF A FLUIDIZED BED BOILER | Improbed AB (SE) | 2022-02-09 | — | — | EP | claimed |
| CN-113887131-A | Responsibility sensitive safety model calibration method facing vehicle cut-in scene | 同济大学 | 2022-01-04 | — | — | CN | claimed |
| US-11074500-B2 | Prediction of social media postings as trusted news or as types of suspicious news | BATTELLE MEMORIAL INSTITUTE (US) | 2021-07-27 | — | — | US | claimed |
| US-6340689-B1 | CONTACTING ATYPICAL UPPER RESPIRATORY PATHOGENIC BACTERIA, ESPECIALLY LEGIONELLA SPECIES, WITH ANTIBACTERIALLY EFFECTIVE AMOUNT OF COMPOSITION COMPRISING GEMIFLOXACIN COMPOUND OR ANTIBACTERIALLY EFFECTIVE DERIVATIVE THEREOF | SMITHKLINE BEECHAM CORPORATION | 2002-01-22 | — | — | US | claimed |
| US-6331550-B1 | MODULATING METABOLISM OF ANAEROBIC PATHOGENIC BACTERIA BY CONTACTING BACTERIA WITH ANTIBACTERIALLY EFFECTIVE AMOUNT OF COMPOSITION COMPRISING GEMIFLOXACIN COMPOUND OR DERIVATIVE | SMITHKLINE BEECHAM CORPORATION | 2001-12-18 | — | — | US | claimed |
| US-6262071-B1 | ADMINISTERING A GEMIFLOXACIN COMPOUND, OR ANTIBACTERIALLY EFFECTIVE DERIVATIVES THEREOF. | SMITHKLINE BEECHAM CORPORATION | 2001-07-17 | — | — | US | claimed |
| WO-2001000209-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-04 | — | — | WO | claimed |
| US-5962468-A | ANTIBACTERIAL ACTIVITY | LG CHEMICAL LTD. (KR) | 1999-10-05 | — | — | US | claimed |
| EP-0465511-B1 | DYNAMIC CORRECTION OF SERVO FOLLOWING ERRORS IN A COMPUTER-NUMERICALLY-CONTROLLED SYSTEM AND FIXED CYCLE UTILIZING SAME | VICKERS ESD INC (US) | 1998-10-07 | — | — | EP | claimed |
| US-5776944-A | 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof | LG CHEMICAL LTD. (KR) | 1998-07-07 | — | — | US | claimed |
| EP-0766157-A2 | Improvements in and relating to dynamic correction of servo following errors in a computer-numerically-controlled system and fixed cycle utilising same | Vickers E.S.D., Inc. (US) | 1997-04-02 | — | — | EP | claimed |
| EP-0465511-A1 | DYNAMIC CORRECTION OF SERVO FOLLOWING ERRORS IN A COMPUTER-NUMERICALLY-CONTROLLED SYSTEM AND FIXED CYCLE UTILIZING SAME | Vickers E.S.D., Inc. (US) | 1992-01-15 | — | — | EP | claimed |
| WO-1990011574-A1 | DYNAMIC CORRECTION OF SERVO FOLLOWING ERRORS IN A COMPUTER-NUMERICALLY-CONTROLLED SYSTEM AND FIXED CYCLE UTILIZING SAME | CINCINNATI MILACRON, INC. (US) | 1990-10-04 | — | — | WO | claimed |