Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | DPP4 | P27487 | 6/20 | 0.93 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.93 |
| ▸ | DRD1 | P21728 | 1/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gemifloxacin SCHEMBL136827 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL2421086 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3141327 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL1237121 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL29408809 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5661711 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5661708 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3281156 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3281159 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5658681 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603875-B1 | NEW PROCESS FOR PREPARING 4-AMINOMETHYL-3-ALKOXYIMINOPYRROLIDINE METHANESULFONATE | LG LIFE SCIENCES LTD (KR) | 2011-09-21 | — | — | EP | claimed |
| US-7687629-B2 | Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | LG LIFE SCIENCES LTD. (KR) | 2010-03-30 | — | — | US | claimed |
| EP-1603875-A4 | NEW PROCESS FOR PREPARING 4-AMINOMETHYL-3-ALKOXYIMINOPYRROLIDINE METHANESULFONATE | LG LIFE SCIENCES LTD (KR) | 2008-11-19 | — | — | EP | claimed |
| EP-1412078-B1 | PROCESSES FOR THE PRODUCTION OF AMINO-PROTECTED DERIVATIVES OF 4-AMINOMETHYLENE-PYRROLIDIN-3-ONE, GEMIFLOXACIN OR A SALT THEREOF | LG LIFE SCIENCES LTD (KR) | 2008-10-08 | — | — | EP | claimed |
| US-20070282107-A1 | New process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | LG LIFE SCIENCES LTD. | 2007-12-06 | — | — | US | claimed |
| US-7232907-B2 | Process for production of naphthyridine-3-carboxylic acid derivatives | LG LIFE SCIENCES LIMITED (KR) | 2007-06-19 | — | — | US | claimed |
| US-7199242-B2 | Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof | LG LIFE SCIENCES LIMITED (KR) | 2007-04-03 | — | — | US | claimed |
| US-20060173195-A1 | Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | LG CHEM, LTD. (KR) | 2006-08-03 | — | — | US | claimed |
| EP-1603875-A1 | NEW PROCESS FOR PREPARING 4-AMINOMETHYL-3-ALKOXYIMINOPYRROLIDINE METHANESULFONATE | LG Life Sciences Ltd (KR) | 2005-12-14 | — | — | EP | claimed |
| US-20050176961-A1 | Process for production of naphthyridine-3-carboxylic acid derivatives | SB PHARMCO PUERTO RICO INC. | 2005-08-11 | — | — | US | claimed |
| EP-1068182-B1 | PROCESS FOR PREPARING A PROTECTED 4-AMINOMETHYL-PYRROLIDIN-3-ONE | LG LIFE SCIENCES LTD (KR) | 2005-06-08 | — | — | EP | claimed |
| US-20050043546-A1 | Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof | LG CHEM, LTD. (KR) | 2005-02-24 | — | — | US | claimed |
| WO-2004092129-A1 | NEW PROCESS FOR PREPARING 4-AMINOMETHYL-3-ALKOXYIMINOPYRROLIDINE METHANESULFONATE | LG LIFE SCIENCES LTD. (KR) | 2004-10-28 | — | — | WO | claimed |
| US-6803467-B2 | ANTIBACTERIAL ACTIVITY | LG LIFE SCIENCES LIMITED (KR) | 2004-10-12 | — | — | US | claimed |
| US-20040138292-A1 | Intermediates for the production of quinolone carboxylic acid derivatives | SB Pharmco Puerto Rico Inc of the United States Corporation Company. | 2004-07-15 | — | — | US | claimed |
| EP-1214321-B1 | PROCESS FOR PRODUCTION OF NAPHTHYRIDINE-3-CARBOXYLIC ACID DERIVATIVES | LG LIFE SCIENCES LTD (KR) | 2004-07-14 | — | — | EP | claimed |
| EP-1212321-B1 | INTERMEDIATES FOR THE PRODUCTION OF NAPHTHYRIDINE-3-CARBOXYLIC ACID DERIVATIVES | LG LIFE SCIENCES LTD (KR) | 2004-07-07 | — | — | EP | claimed |
| EP-1412078-A1 | PROCESSES FOR THE PRODUCTION OF AMINO-PROTECTED DERIVATIVES OF 4-AMINOMETHYLENE-PYRROLIDIN-3-ONE AND/OR 4-AMINOMETHYLENE-PYRROLIDIN-3-ALKOXYIMINO DERIVATIVES AND/OR GEMIFLOXACIN OR A SALT THEREOF | SB Pharmco Puerto Rico Inc (US) | 2004-04-28 | — | — | EP | claimed |
| WO-2003011450-A1 | PROCESSES FOR THE PRODUCTION OF AMINO-PROTECTED DERIVATIVES OF 4-AMINOMETHYLENE-PYRROLIDIN-3-ONE AND/OR 4-AMINOMETHYLENE-PYRROLIDIN-3-ALKOXYIMINO DERIVATIVES AND/OR GEMIFLOXACIN OR A SALT THEREOF | LG LIFE SCIENCES LIMITED (KR) | 2003-02-13 | — | — | WO | claimed |
| US-6307059-B1 | PREPARATION OF QUINOLONE ANTIBIOTICS. | LG CHEMICAL, LTD (KR) | 2001-10-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043546-A1 | Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof | CYP4X1, PM20D2, BRIX1 | LMNA 3130/4885KDM4E 551/4885HSD17B10 4114/4885 |
| US-20070282107-A1 | New process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | MLN, AAAS, ACMSD | LMNA 1610/4885KDM4E 333/4885HSD17B10 3607/4885 |
| US-20050176961-A1 | Process for production of naphthyridine-3-carboxylic acid derivatives | NRDC, NDC1, NQO2 | LMNA 1345/4885KDM4E 3931/4885HSD17B10 693/4885 |
| US-20060173195-A1 | Process for preparing 4-aminomethyl-3-alkoxyiminopyrrolidine methanesulfonate | MLN, ACMSD, AAAS | LMNA 1474/4885KDM4E 249/4885HSD17B10 3782/4885 |
| US-20040138292-A1 | Intermediates for the production of quinolone carboxylic acid derivatives | NQO2, COASY, SDHA | LMNA 3607/4885KDM4E 3173/4885HSD17B10 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.