Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | DPP4 | P27487 | 6/20 | 0.93 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.93 |
| ▸ | DRD1 | P21728 | 1/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gemifloxacin SCHEMBL136827 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL2421086 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3141327 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL1237121 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL2421087 | 1.00 | LMNA (1.00) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5661711 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5661708 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3281156 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL3281159 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 | |
| Gemifloxacin SCHEMBL5658681 | 0.99 | LMNA (0.98) | LMNAKDM4EHSD17B10ABCC4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180649-B1 | COMPACT FOLDING ARCHITECTURE FOR HEAD MOUNTED DEVICE | GOOGLE LLC (US) | 2022-02-23 | — | — | EP | claimed |
| US-20260041258-A1 | SELF-CLOSING SECURITY DOOR ASSEMBLY FOR RETAIL DISPLAY | VIRA INSIGHT LLC (US) | 2026-02-12 | — | — | US | disclosed |
| US-12502012-B2 | Self-closing security door assembly for retail display | VIRA INSIGHT, LLC (US) | 2025-12-23 | — | — | US | disclosed |
| US-12492146-B2 | Solvent cement formulations | OATEY CO. (US) | 2025-12-09 | — | — | US | disclosed |
| US-20250185824-A1 | SELF-CLOSING SECURITY DOOR ASSEMBLY FOR RETAIL DISPLAY | JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE ASSISTANT | 2025-06-12 | — | — | US | disclosed |
| US-20250121019-A1 | METHODS AND SYSTEMS FOR MAKING OIL-LOADED POWDERS AND USE THEREOF | Medisca Pharmaceutique Inc. (CA) | 2025-04-17 | — | — | US | disclosed |
| EP-4499286-A1 | METHODS AND SYSTEMS FOR MAKING OIL-LOADED POWDERS AND USE THEREOF | MEDISCA PHARMACEUTIQUE INC. (CA) | 2025-02-05 | — | — | EP | disclosed |
| US-20240326036-A1 | APPARATUS FOR GAS SAMPLE COLLECTION | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2024-10-03 | — | — | US | disclosed |
| CN-113407248-B | Active defense method for DDoS attack in sensing edge cloud based on flow weight control | 绍兴文理学院 | 2024-06-21 | — | — | CN | disclosed |
| WO-2024103168-A1 | METHODS AND SYSTEMS FOR MAKING OIL-LOADED POWDERS AND USE THEREOF | Medisca Pharmaceutique Inc. (CA) | 2024-05-23 | — | — | WO | disclosed |
| EP-4217185-A1 | SOLVENT CEMENT FORMULATIONS | Oatey Co. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2023102638-A2 | APPARATUS FOR GAS SAMPLE COLLECTION | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2023-06-15 | — | — | WO | disclosed |
| US-20220234336-A1 | SOFTBOOTS AND WATERPROOF/BREATHABLE MOISTURE TRANSFER COMPOSITE AND LINER FOR IN-LINE SKATES, ICE-SKATES, HOCKEY SKATES, SNOWBOARD BOOTS, ALPINE BOOTS, HIKING BOOTS AND THE LIKE | SOLID WATER HOLDINGS (US) | 2022-07-28 | — | — | US | disclosed |
| WO-2022140849-A1 | CANNABINOID COMPOSITIONS WITH TASTE-BARRIER PROPERTIES | HEXO OPERATIONS INC. (CA) | 2022-07-07 | — | — | WO | disclosed |
| US-11336622-B2 | Apparatus and method for deploying firewall on SDN and network using the same | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2022-05-17 | — | — | US | disclosed |
| US-11329988-B2 | Access to a service in a network | TELEFONAKTIEBOLAGET LM ERICSSON (PUBL) (SE) | 2022-05-10 | — | — | US | disclosed |
| WO-2022066684-A1 | SOLVENT CEMENT FORMULATIONS | OATEY CO. (US) | 2022-03-31 | — | — | WO | disclosed |
| EP-3646544-B1 | ACCESS TO A SERVICE IN A NETWORK | ERICSSON TELEFON AB L M (SE) | 2022-03-30 | — | — | EP | disclosed |
| US-20220089493-A1 | Solvent Cement Formulations | OATEY CO. | 2022-03-24 | — | — | US | disclosed |
| EP-3180649-B1 | COMPACT FOLDING ARCHITECTURE FOR HEAD MOUNTED DEVICE | GOOGLE LLC (US) | 2022-02-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260041258-A1 | SELF-CLOSING SECURITY DOOR ASSEMBLY FOR RETAIL DISPLAY | RACK1, RNF10, CBL | LMNA 722/4885KDM4E 2212/4885HSD17B10 4127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.