Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184155 | 0.79 | NOTUM (0.38) | NOTUMIDO1CYP3A4HSD17B10LMNA | |
| SCHEMBL13683029 | 0.72 | PDE3B (0.36) | CYP3A4CYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL8470256 | 0.71 | CYP3A4 (0.37) | NOTUMIDO1CYP3A4HSD17B10LMNA | |
| SCHEMBL16200121 | 0.69 | CYP3A4 (0.38) | CYP3A4LMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13683019 | 0.69 | NOTUM (0.43) | NOTUMCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL16200120 | 0.69 | NOTUM (0.41) | NOTUMIDO1CYP3A4HSD17B10LMNA | |
| SCHEMBL13683028 | 0.69 | ADORA2A (0.44) | NOTUMLMNAMAPTALDH1A1MEN1 | |
| SCHEMBL13683119 | 0.69 | ADORA2A (0.35) | CYP1A2CYP2D6CYP2C19ALDH1A1KDM4E | |
| SCHEMBL13140354 | 0.68 | NOTUM (0.47) | NOTUMIDO1CYP3A4HSD17B10LMNA | |
| SCHEMBL13683025 | 0.67 | RAB9A (0.42) | MAPTALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |