Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | IL6 | P05231 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200239 | 0.86 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL14044167 | 0.80 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL13184129 | 0.80 | SMN1; SMN2 (0.35) | ALDH1A1SMN1; SMN2LMNAKDM4EKMT2A | |
| SCHEMBL14139364 | 0.74 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL13683150 | 0.70 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL13184123 | 0.68 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL13184421 | 0.68 | NOTUM (0.41) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL13184179 | 0.66 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL13184193 | 0.66 | NOTUM (0.47) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL14044042 | 0.64 | NOTUM (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |