Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ADCY10 | Q96PN6 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683149 | 0.86 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL14044167 | 0.80 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL16200250 | 0.74 | KLKB1 (0.33) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14043869 | 0.72 | — | — | |
| SCHEMBL14043991 | 0.70 | IRAK4 (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL14044204 | 0.69 | PDE1A (0.31) | — | |
| SCHEMBL13184123 | 0.68 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2LMNAMAPTAPOBEC3G | |
| SCHEMBL13184421 | 0.68 | NOTUM (0.41) | ALDH1A1SMN1; SMN2LMNAMAPTGAA | |
| SCHEMBL14043735 | 0.66 | POLB (0.31) | — | |
| SCHEMBL13184129 | 0.66 | SMN1; SMN2 (0.35) | ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |