Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13683149 | 0.80 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL16200239 | 0.80 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL13184123 | 0.73 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL13184421 | 0.73 | NOTUM (0.41) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL16200283 | 0.70 | CCR1 (0.48) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL14044042 | 0.69 | NOTUM (0.36) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL13683018 | 0.69 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL30197714 | 0.68 | PDE4B (0.32) | LMNATACR3 | |
| SCHEMBL16200387 | 0.67 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2GAAHPGDTHRB | |
| SCHEMBL2118604 | 0.66 | LMNA (0.35) | LMNATACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |