Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723041 | 0.88 | GPR119 (0.55) | GPR119FLT3CDK2CDK6S1PR1 | |
| SCHEMBL4719883 | 0.88 | GPR119 (0.51) | GPR119FLT3CDK2CDK6S1PR1 | |
| SCHEMBL391509 | 0.88 | GPR119 (0.54) | GPR119IKBKETBK1 | |
| SCHEMBL4723673 | 0.85 | GPR119 (0.51) | GPR119FLT3CDK2CDK6S1PR1 | |
| SCHEMBL4721934 | 0.85 | GPR119 (0.51) | GPR119FLT3CDK2CDK6EGFR | |
| SCHEMBL4721912 | 0.83 | GPR119 (0.38) | GPR119FLT3CDK2CDK6S1PR1 | |
| SCHEMBL13685341 | 0.83 | GPR119 (0.53) | GPR119FLT3CDK2CDK6S1PR1 | |
| SCHEMBL4719405 | 0.83 | GPR119 (0.48) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4720455 | 0.82 | GPR119 (0.42) | GPR119FLT3CDK2CDK6S1PR1 | |
| SCHEMBL4719099 | 0.82 | GPR119 (0.37) | GPR119FLT3CDK2CDK6S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |