Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245273 | 0.80 | BRD4 (0.41) | BRD4KDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL12356714 | 0.80 | NCF1 (0.42) | BRD4HPGDPOLB | |
| SCHEMBL2248077 | 0.67 | PARP1 (0.35) | BRD4ALDH1A1POLBLMNAMAPT | |
| SCHEMBL13040635 | 0.67 | KEAP1 (0.49) | KDM4EHPGDNR3C1HTTTP53 | |
| SCHEMBL2907371 | 0.66 | MAPT (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL12356715 | 0.66 | NCF1 (0.44) | ALDH1A1HPGDSMN1; SMN2NR3C1LMNA | |
| SCHEMBL2907292 | 0.65 | NPC1 (0.42) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL2245184 | 0.65 | NPC1 (0.39) | BRD4KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2901726 | 0.63 | MAPT (0.46) | BRD4KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2901907 | 0.63 | SMN1; SMN2 (0.42) | ALDH1A1HPGDSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262774-B1 | 2-aminoquinolines as 5-HT5A receptor antagonists, their manufacture and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |