Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.58 |
| ▸ | GPR4 | P46093 | 5/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450983 | 0.86 | CTSK (0.61) | CTSKGPR4 | |
| SCHEMBL13686017 | 0.86 | CTSK (0.69) | CTSKGPR4PTGS1 | |
| SCHEMBL3451762 | 0.80 | CTSK (0.69) | CTSKGPR4 | |
| SCHEMBL3450602 | 0.79 | CTSK (0.67) | CTSKGPR4 | |
| SCHEMBL3451100 | 0.78 | CTSK (0.64) | CTSKGPR4FGFR4 | |
| SCHEMBL6219864 | 0.77 | CTSK (0.71) | CTSKGPR4 | |
| SCHEMBL6219623 | 0.77 | CTSK (0.71) | CTSKGPR4FGFR4 | |
| SCHEMBL13125028 | 0.77 | CTSK (0.78) | CTSKGPR4 | |
| SCHEMBL3451395 | 0.76 | CTSK (0.80) | CTSKGPR4 | |
| SCHEMBL3450123 | 0.75 | CTSK (1.00) | CTSKGPR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227596-A1 | HETEROARYL NITRILE DERIVATIVES | NOVARTIS AG (CH) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227596-A1 | HETEROARYL NITRILE DERIVATIVES | CTSK, CTSS, CTSZ | CTSK 1/4885GPR4 1795/4885FGFR4 1261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.