Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690750 | 0.90 | GPR119 (0.49) | GPR119KDM4EPKMPRMT5ABL1 | |
| SCHEMBL13690341 | 0.90 | GPR119 (0.49) | GPR119KDM4EPKMPRMT5ABL1 | |
| SCHEMBL4056484 | 0.88 | KDM4E (0.52) | GPR119KDM4EPKMPRMT5KDM1A | |
| SCHEMBL13690383 | 0.88 | GPR119 (0.51) | GPR119KDM4EPKMPRMT5KDM1A | |
| SCHEMBL13690395 | 0.85 | GPR119 (0.56) | GPR119KDM4EPKMPRMT5KDM1A | |
| SCHEMBL13690346 | 0.84 | GPR119 (0.48) | GPR119KDM4EPKMPRMT5KDM1A | |
| SCHEMBL13690526 | 0.84 | GPR119 (0.48) | GPR119KDM4EPKMPRMT5KDM1A | |
| SCHEMBL13690387 | 0.83 | GPR119 (0.59) | GPR119 | |
| SCHEMBL13690524 | 0.83 | PRMT5 (0.46) | GPR119KDM4EPKMPRMT5KDM1A | |
| SCHEMBL14191027 | 0.81 | GPR119 (0.73) | GPR119HDAC1TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |