Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | TPH1 | P17752 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690750 | 0.97 | GPR119 (0.49) | GPR119KDM4EPKMPRMT5HDAC1 | |
| SCHEMBL13690458 | 0.90 | GPR119 (0.49) | GPR119KDM4EPKMPRMT5ATR | |
| SCHEMBL4056484 | 0.88 | KDM4E (0.52) | GPR119KDM4EPKMPRMT5HDAC1 | |
| SCHEMBL13690383 | 0.88 | GPR119 (0.51) | GPR119KDM4EPKMPRMT5HDAC1 | |
| SCHEMBL4373471 | 0.86 | ATR (0.50) | ATRTBK1TPH1 | |
| SCHEMBL13690457 | 0.85 | GPR119 (0.56) | GPR119ATRHDAC1 | |
| SCHEMBL13690395 | 0.85 | GPR119 (0.56) | GPR119KDM4EPKMPRMT5KDM1A | |
| SCHEMBL13690526 | 0.84 | GPR119 (0.48) | GPR119KDM4EPKMPRMT5HDAC1 | |
| SCHEMBL13690346 | 0.84 | GPR119 (0.48) | GPR119KDM4EPKMPRMT5HDAC1 | |
| SCHEMBL13690524 | 0.83 | PRMT5 (0.46) | GPR119KDM4EPKMPRMT5KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |