Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | TPH1 | P17752 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690383 | 0.92 | GPR119 (0.51) | KDM4EPKMGPR119PRMT5TPH1 | |
| SCHEMBL13690395 | 0.89 | GPR119 (0.56) | KDM4EPKMGPR119PRMT5KDM1A | |
| SCHEMBL13690341 | 0.88 | GPR119 (0.49) | KDM4EPKMGPR119PRMT5TPH1 | |
| SCHEMBL13690750 | 0.88 | GPR119 (0.49) | KDM4EPKMGPR119PRMT5TPH1 | |
| SCHEMBL13690458 | 0.88 | GPR119 (0.49) | KDM4EPKMGPR119PRMT5KDM1A | |
| SCHEMBL13690524 | 0.87 | PRMT5 (0.46) | KDM4EPKMGPR119PRMT5TPH1 | |
| SCHEMBL13690387 | 0.87 | GPR119 (0.59) | GPR119 | |
| SCHEMBL13690526 | 0.85 | GPR119 (0.48) | KDM4EPKMGPR119PRMT5TPH1 | |
| SCHEMBL13690346 | 0.85 | GPR119 (0.48) | KDM4EPKMGPR119PRMT5TPH1 | |
| SCHEMBL13690475 | 0.83 | GPR119 (0.59) | KDM4EPKMGPR119HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |