Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | TDP2 | O95551 | 2/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15788033 | 0.86 | CYP11B1 (0.41) | CYP11B1CYP11B2TDP2TGM2CES1 | |
| SCHEMBL10916724 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2PDE3BPDE3AKCNH2 | |
| SCHEMBL787497 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2TDP2TGM2CES1 | |
| SCHEMBL30695802 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2TDP2TGM2CES1 | |
| SCHEMBL3068531 | 0.79 | AHR (0.56) | CYP11B1CYP11B2TGM2CES1PDE3B | |
| SCHEMBL434348 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2PDE3BPDE3AKCNH2 | |
| SCHEMBL3597262 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2PDE3BPDE3AKCNH2 | |
| SCHEMBL31261247 | 0.79 | CYP11B1 (0.51) | CYP11B1CYP11B2PDE3BPDE3AKCNH2 | |
| SCHEMBL21377526 | 0.79 | TDP2 (0.34) | CYP11B1CYP11B2TDP2TGM2CES1 | |
| SCHEMBL3597266 | 0.79 | LMNA (0.51) | CYP11B1CYP11B2PDE3BPDE3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288945-B1 | IMIDAZOPYRAZINES AND PYRAZOLOPYRIMIDINES AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-18 | — | — | EP | disclosed |
| WO-2009106577-A1 | IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |